NAD+ - Research Grade Peptide

NAD+ – Research-Grade Oxidised Dinucleotide Coenzyme

For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, consumption, clinical use or therapeutic application. It must not be used in any way that contravenes applicable laws or the requirements of the Medicines and Healthcare products Regulatory Agency.

• Research-grade oxidised nicotinamide adenine dinucleotide with batch documentation available where supplied
• Defined dinucleotide coenzyme supplied in the NAD+ oxidised molecular form
• Supplied as measured lyophilised or dry laboratory material in sealed flip-top headspace vials
• Batch identity, assay, chromatographic purity, water content and analytical specifications stated in the applicable Certificate of Analysis
• Handled and supplied exclusively as a research-use laboratory biochemical

NAD+, also known as oxidised nicotinamide adenine dinucleotide, beta-NAD or nadide, is a dinucleotide coenzyme rather than a peptide. Each vial contains measured laboratory material prepared to support controlled scientific handling, storage and analytical investigation. The stated nominal amount refers to the declared NAD+ content of a single vial, subject to the applicable batch documentation. Where dissolution is required, the solvent, buffer, concentration, handling procedure and storage conditions stated in the applicable Certificate of Analysis, Safety Data Sheet or validated laboratory method should be followed. We do not provide advice or recommendations concerning dosage, administration or use in humans or animals.

Chemical and Structural Information:

• Product Name: NAD+
• Preferred Technical Name: Beta-nicotinamide adenine dinucleotide, oxidised form
• Alternative Names: Nicotinamide adenine dinucleotide; beta-NAD+; beta-NAD; beta-DPN; diphosphopyridine nucleotide; coenzyme I; cozymase; nadide
• Material Classification: Oxidised dinucleotide coenzyme and pyridinium nucleotide
• Peptide Status: NAD+ is not a peptide and does not contain an amino-acid sequence
• Structural Description: An adenine ribonucleotide and a nicotinamide ribonucleotide joined through a diphosphate or pyrophosphate linkage
• Oxidation State: Oxidised NAD+ form
• Anomeric Form: Beta form where confirmed by the applicable batch specification
• CAS Registry Number: 53-84-9
• CAS Name: NAD
• PubChem Compound Identifier: CID 5893
• ChEBI Identifier: CHEBI:15846
• European Community Number: 200-184-4
• Common Anhydrous Free-Acid Formula: C₂₁H₂₇N₇O₁₄P₂
• Average Molecular Weight on an Anhydrous Free-Acid Basis: Approximately 663.43 g/mol
• Formal NAD+ Cation Representation: C₂₁H₂₈N₇O₁₄P₂⁺
• Average Molecular Weight of the Formal Protonated Cation Representation: Approximately 664.44 g/mol
• Formula Representation Note: Chemical databases may display NAD+ using different protonation and formal-charge conventions. The common 663.43 g/mol catalogue value describes the anhydrous free-acid empirical formula, while formally protonated ionic representations may differ by one hydrogen atom and approximately one mass unit
• Systematic Name: Adenosine 5′-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
• Physical Form: Solid lyophilised or dry laboratory material, as stated in the applicable batch Certificate of Analysis
• Appearance: White to off-white laboratory material, subject to confirmation in the applicable batch Certificate of Analysis
• Assay Specification: The applicable NAD+ assay result, analytical method, calculation basis and acceptance criterion should be stated in the batch Certificate of Analysis
• Chromatographic Purity: The applicable high-performance liquid chromatography purity result and method should be stated in the batch Certificate of Analysis
• Oxidised-Form Purity: The proportion of oxidised NAD+ should be distinguished from total material assay and from the presence of reduced NADH or other nucleotide-related impurities
• Reduced-Form Distinction: NADH is the reduced form of nicotinamide adenine dinucleotide and is a separate molecular species with different oxidation state, analytical characteristics and molecular identity
• NADP+ Distinction: Nicotinamide adenine dinucleotide phosphate contains an additional phosphate group and should not be represented using the NAD+ formula or CAS number
• Salt-Form Confirmation: The applicable Certificate of Analysis should identify whether the supplied material is the free-acid form, a sodium salt, another counter-ion form or a formulated preparation
• Hydration-State Confirmation: Residual water and hydrate content may affect the total material mass and assay on an as-is basis and should be stated or controlled through the batch specification
• Nominal Amount Basis: The product specification should state whether the declared vial amount is calculated as anhydrous NAD+ equivalent or as total supplied material including residual water, salt-form components or excipients
• Purity and Assay Interpretation: Chromatographic purity, oxidation-state purity, assay, water content, salt content and total vial mass are separate measurements and should not be treated as interchangeable
• Related-Substance Control: Reduced NADH, nicotinamide, adenine-containing nucleotides, hydrolysis products, nucleotide fragments and other structurally related or process-related substances should be controlled as appropriate to the batch specification
• Residual-Solvent Specification: Applicable residual solvents arising from production, extraction, chromatography, concentration or lyophilisation should be stated or controlled through the batch specification
• Endotoxin Specification: The applicable bacterial endotoxin or lipopolysaccharide result, analytical method, reporting units, method-suitability controls and acceptance criterion should be stated in the batch Certificate of Analysis
• Analytical Interpretation: Molecular identity, oxidation state, anomeric form, chromatographic purity, assay, salt form, hydration state, water content, residual solvents, related substances and bacterial endotoxin results are separate quality attributes and should be interpreted together

✓ Batch documentation – Completed Certificate of Analysis documentation is provided where supplied for the applicable batch.
✓ Certificate of Analysis – Accessible through the product QR code where a completed batch-specific document has been published.
✓ Safety Data Sheet – Supplied to support appropriate laboratory handling, storage and regulatory compliance.
✓ Chemical-identity documentation – The CAS number, molecular formula, oxidation state and beta-anomeric form should be confirmed using the applicable batch records.
✓ Chromatographic documentation – The reported high-performance liquid chromatography purity applies only to the analytical method and batch stated in the Certificate of Analysis.
✓ Assay documentation – NAD+ assay should be distinguished from chromatographic purity and interpreted alongside water, salt-form and residual-solvent results.
✓ Oxidation-state documentation – Oxidised NAD+ should be distinguished analytically from reduced NADH and other related nucleotide substances.
✓ Chemical-form documentation – The free-acid form, sodium salt, hydrate or another supplied form should be identified clearly in the applicable product and batch records.
✓ Water-content documentation – Residual water and hydration state should be stated or controlled where they contribute to the total material mass.
✓ Bacterial endotoxin documentation – The applicable bacterial endotoxin or lipopolysaccharide result should identify the test method, reporting units, method-suitability controls and acceptance criterion.
✓ Supplier documentation – Reviewed where supporting production, purification and analytical records are supplied.
✓ Fast, reliable and trackable express delivery – Securely packaged and dispatched using insulated or temperature-managed packaging where required by the applicable transport and storage specification.

For Research Use Only
This product is supplied strictly for scientific research, laboratory analysis and experimental work. It is not intended for human consumption, animal use, clinical use, diagnostic use or any form of therapeutic application.

NAD+ Product Overview

Our NAD+ research-grade oxidised dinucleotide coenzyme, also known as beta-nicotinamide adenine dinucleotide, beta-NAD or nadide, is supplied for controlled scientific laboratory investigation, biochemical assay development, analytical method development, high-performance liquid chromatography assessment, mass-spectrometry workflows, enzymology and reference-material comparison.

NAD+ comprises nicotinamide and adenine ribonucleotide components joined through a diphosphate linkage. It is the oxidised member of the NAD+/NADH redox pair and should not be confused with reduced NADH, phosphorylated NADP+, nicotinamide riboside, nicotinamide mononucleotide or other structurally related biochemical materials.

The material is handled with a focus on batch traceability, documented quality control and consistent laboratory presentation. Product identity, oxidation state, anomeric form, chromatographic purity, assay, salt form, hydration state, water content, residual solvents, related substances, bacterial endotoxin results and other analytical specifications should be confirmed using the applicable batch Certificate of Analysis.

The CAS number 53-84-9, molecular formula C₂₁H₂₇N₇O₁₄P₂ and average molecular weight of approximately 663.43 g/mol describe the commonly used anhydrous free-acid empirical representation. Formal ionic representations may show a different hydrogen count and molecular weight according to the protonation and charge convention applied.

Chromatographic purity should not automatically be interpreted as equivalent to the total NAD+ assay or the net anhydrous NAD+ content of the vial. Likewise, a bacterial endotoxin or lipopolysaccharide result does not establish sterility, oxidation-state purity, molecular identity, anomeric identity or the absence of every nucleotide-related and process-related impurity.

For the majority of routine biochemical assays, analytical method development, enzymology, reference-material comparison and general laboratory work, the Regular NAD+ specification remains highly suitable. The premium black-and-gold ULTIMATE NAD+ option provides an additional preparative high-performance liquid chromatography purification stage and a more stringent bacterial endotoxin and lipopolysaccharide testing specification for scientific projects requiring enhanced quality-control parameters.

View Certificate of Analysis

View Safety Data Sheet