SNAP-8 (Acetyl Octapeptide-3) - Research Grade Peptide

SNAP-8 (Acetyl Octapeptide-3) – Research-Grade N-Acetylated Octapeptide

For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, consumption, clinical use or therapeutic application. It must not be used in any way that contravenes applicable laws or the requirements of the Medicines and Healthcare products Regulatory Agency.

• Research-grade synthetic Acetyl Octapeptide-3 with batch documentation available where supplied
• Defined linear sequence comprising eight amino-acid residues
• N-terminally acetylated and C-terminally amidated molecular structure
• Supplied as measured dry or lyophilised laboratory material in sealed flip-top headspace vials
• Batch identity, chromatographic purity, peptide content and analytical specifications stated in the applicable Certificate of Analysis
• Handled and supplied exclusively as a research-use laboratory material

All of our research peptides and related laboratory materials are supplied strictly for scientific research and laboratory use only. Each vial contains measured dry or lyophilised material prepared to support controlled laboratory handling, storage and analytical investigation. The stated nominal amount refers to the declared SNAP-8 or Acetyl Octapeptide-3 content of a single vial, subject to the applicable batch documentation. Where dissolution or reconstitution is required, the solvent, buffer, concentration, mixing procedure and storage conditions stated in the applicable Certificate of Analysis, Safety Data Sheet or validated laboratory method should be followed. We do not provide advice or recommendations concerning dosage, administration or use in humans or animals.

Chemical and Structural Information:

• Product Name: SNAP-8 (Acetyl Octapeptide-3)
• Preferred Substance Name: Acetyl Octapeptide-3
• Alternative Names: SNAP-8; SNAP8; Acetyl Octapeptide-3
• Material Classification: Synthetic N-terminally acetylated and C-terminally amidated linear octapeptide
• Sequence Length: Eight amino-acid residues
• Complete Modified Peptide Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
• Modified One-Letter Sequence: Ac-EEMQRRAD-NH₂
• Unmodified Core Sequence: Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp
• N-Terminal Structure: Covalently N-acetylated glutamic acid
• C-Terminal Structure: C-terminally amidated aspartic acid residue
• Acetylation Clarification: The N-terminal acetyl group forms part of the covalent molecular structure and is not an acetate counter-ion
• Cyclic or Linear Structure: Linear peptide
• Cysteine Content: None
• Disulphide-Bond Content: None; the SNAP-8 sequence contains no cysteine residues
• Methionine Content: One methionine residue
• CAS Number: 868844-74-0
• Molecular Formula: C₄₁H₇₀N₁₆O₁₆S
• Average Molecular Weight: Approximately 1075.17 g/mol
• Reference InChIKey: KMACPCJUCHVVGP-FNRPHRCSSA-N
• Formula Basis: The molecular formula and molecular weight describe the defined SNAP-8 covalent structure containing its N-terminal acetyl group and C-terminal amide, without additional counter-ions, residual water, solvents or formulation excipients
• Physical Form: Dry powder or lyophilised laboratory material, as stated in the applicable batch Certificate of Analysis
• Appearance: Refer to the applicable batch Certificate of Analysis
• Purity Specification: The applicable chromatographic purity result, analytical method and acceptance criterion are stated in the batch Certificate of Analysis
• Purity Interpretation: Chromatographic purity represents the relative chromatographic composition measured under the stated analytical conditions and should not automatically be interpreted as equivalent to total net SNAP-8 peptide content
• Peptide-Content Specification: Net Acetyl Octapeptide-3 content should be distinguished from chromatographic purity and interpreted alongside water, counter-ion, residual-solvent and formulation results
• Sequence Confirmation: The complete eight-residue Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp sequence should be confirmed using the applicable synthesis, supplier and batch records
• N-Terminal Acetylation Confirmation: Product identity should confirm the presence and position of the covalent N-terminal acetyl group using suitable mass-spectrometry or equivalent molecular-identity data
• C-Terminal Amidation Confirmation: Molecular-identity documentation should confirm the amidated C-terminal aspartic acid residue and distinguish it from a free carboxylic acid terminal structure
• Mass-Spectrometry Confirmation: Molecular identity should be supported by analytical mass data consistent with the specified SNAP-8 molecular structure
• Chemical-Form Confirmation: The applicable Certificate of Analysis should identify whether the supplied material is the defined peptide alone, a sodium form, an acetate-containing form, a trifluoroacetate-containing form or another counter-ion presentation
• Counter-Ion Specification: Sodium, acetate, trifluoroacetate or another counter-ion may affect the total supplied material mass and calculated net peptide content
• Nominal Amount Basis: The applicable product specification should state whether the declared vial quantity is expressed as net SNAP-8 peptide equivalent or as total supplied salt-form or formulated material
• Water-Content Specification: Residual water may contribute to the total material mass and should be stated or controlled through the applicable batch specification
• Residual-Solvent Specification: Applicable residual solvents arising from peptide synthesis, cleavage, acetylation, purification, concentration and lyophilisation should be stated or controlled through the batch specification
• Methionine-Oxidation Control: Oxidation of the methionine residue is a distinct peptide-related quality attribute and should be assessed or controlled where required by the applicable batch specification
• Related-Impurity Control: Deletion sequences, truncated peptides, incompletely acetylated material, incompletely amidated material, methionine oxidation products and other synthesis-related or process-related substances are separate quality attributes
• Dissolution Method: The appropriate solvent, buffer, concentration and mixing procedure should be selected using the applicable batch documentation and validated laboratory method; a universal solvent instruction should not be applied to every SNAP-8 preparation
• Endotoxin Specification: The applicable bacterial endotoxin or lipopolysaccharide result, analytical method, reporting units, method-suitability controls and acceptance criterion should be stated in the batch Certificate of Analysis
• Sterility Distinction: A bacterial endotoxin or lipopolysaccharide result does not establish sterility. Sterility should only be claimed where supported by an appropriate validated sterility test and controlled filling process
• Analytical Interpretation: Molecular identity, amino-acid sequence, N-terminal acetylation, C-terminal amidation, chromatographic purity, net peptide content, methionine oxidation, water content, residual solvents, counter-ion content and bacterial endotoxin results are separate analytical measurements and should be interpreted together

✓ Batch documentation – Completed Certificate of Analysis documentation is provided where supplied for the applicable batch.
✓ Certificate of Analysis – Accessible through the product QR code where a completed batch-specific document has been published.
✓ Safety Data Sheet – Supplied to support appropriate laboratory handling, storage and regulatory compliance.
✓ Sequence documentation – The complete eight-residue amino-acid sequence should be confirmed using the applicable synthesis and batch records.
✓ N-terminal modification documentation – Covalent N-terminal acetylation should be supported by appropriate molecular-identity data.
✓ C-terminal modification documentation – C-terminal amidation should be confirmed and distinguished from a free carboxylic acid terminal structure.
✓ Mass-spectrometry documentation – Molecular identity should be supported by analytical mass data consistent with the specified SNAP-8 structure.
✓ Purity documentation – The reported chromatographic purity applies only to the analytical method and batch stated in the Certificate of Analysis.
✓ Peptide-content documentation – Net Acetyl Octapeptide-3 content should be distinguished from chromatographic purity and interpreted alongside water, counter-ion and residual-solvent results.
✓ Oxidation-control documentation – Methionine oxidation should be assessed or controlled where required by the applicable research specification.
✓ Chemical-form documentation – The defined peptide, sodium form, acetate-containing form, trifluoroacetate-containing form or other presentation should be identified clearly in the applicable product and batch records.
✓ Bacterial endotoxin documentation – The applicable bacterial endotoxin or lipopolysaccharide result should identify the test method, reporting units, method-suitability controls and acceptance criterion.
✓ Supplier documentation – Reviewed where supporting synthesis, acetylation, amidation, purification and analytical records are supplied.
✓ Fast, reliable and trackable express delivery – Securely packaged and dispatched using insulated or temperature-managed packaging where required by the applicable transport and storage specification.

For Research Use Only
This product is supplied strictly for scientific research, laboratory analysis and experimental work. It is not intended for human consumption, animal use, clinical use, diagnostic use or any form of therapeutic application.

SNAP-8 Product Overview

Our SNAP-8 research-grade Acetyl Octapeptide-3 is supplied for controlled scientific laboratory investigation, analytical method development, modified peptide characterisation, high-performance liquid chromatography assessment, mass-spectrometry workflows, formulation studies and reference-material comparison.

SNAP-8 comprises the defined Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp octapeptide sequence containing a covalent N-terminal acetyl group and a C-terminal amide. These terminal modifications form part of the molecular identity and should be confirmed through the applicable synthesis records and molecular-identity data.

The material is handled with a focus on batch traceability, documented quality control and consistent laboratory presentation. Product identity, amino-acid sequence, N-terminal acetylation, C-terminal amidation, chromatographic purity, net peptide content, molecular form, counter-ion content, water content, residual solvents, methionine oxidation, bacterial endotoxin results and other analytical specifications should be confirmed using the applicable batch Certificate of Analysis.

The CAS number 868844-74-0, molecular formula C₄₁H₇₀N₁₆O₁₆S and average molecular weight of approximately 1075.17 g/mol describe the defined Acetyl Octapeptide-3 molecular structure. Where the supplied laboratory material contains sodium, acetate, trifluoroacetate, residual water, solvents or formulation ingredients, the applicable batch documentation should identify their contribution to the total supplied material mass.

Chromatographic purity should not automatically be interpreted as equivalent to total net SNAP-8 peptide content. Likewise, a bacterial endotoxin or lipopolysaccharide result does not establish sterility, molecular identity, correct N-terminal acetylation, correct C-terminal amidation, methionine oxidation status or the absence of every peptide-related and process-related impurity.

For the majority of routine analytical, chromatographic, formulation, peptide-characterisation and general laboratory work, the Regular SNAP-8 specification remains highly suitable. The premium black-and-gold ULTIMATE SNAP-8 option provides an additional preparative high-performance liquid chromatography purification stage and a more stringent bacterial endotoxin and lipopolysaccharide testing specification for scientific projects requiring enhanced quality-control parameters.

View Certificate of Analysis

View Safety Data Sheet