BPC-157 & TB500 BLEND - Research Grade Peptide

BPC-157 & TB500 Blend – Research-Grade Dual-Peptide Blend

For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, consumption, clinical use or therapeutic application. It must not be used in any way that contravenes applicable laws or the requirements of the Medicines and Healthcare products Regulatory Agency.

• Defined two-component blend containing BPC-157 and full-length thymosin beta-4
• Formulated at a 1:1 ratio by declared peptide mass unless a product variant expressly states otherwise
• TB500 component defined as full-length 43-residue thymosin beta-4 or timbetasin
• Supplied as measured dry or lyophilised laboratory material in sealed flip-top headspace vials
• Component identity, chromatographic purity, molecular mass and blend composition documented in the applicable completed Certificate of Analysis where supplied
• Handled and supplied exclusively as a research-use laboratory preparation

PEP066 is a defined physical mixture of two separate peptide substances: BPC-157 and full-length thymosin beta-4. The two components remain chemically distinct within the preparation and do not form a new single peptide molecule merely because they are blended in the same vial.

Unless the selected product variant states otherwise, BPC-157 and full-length thymosin beta-4 are included in equal quantities by declared peptide mass. For example, a vial described as containing 20 mg total peptide contains a nominal 10 mg of BPC-157 and 10 mg of full-length thymosin beta-4. The total physical powder mass may be greater where a declared carrier, bulking agent or other formulation excipient is present.

A 1:1 mass ratio is not the same as a 1:1 molar ratio because the two components have substantially different molecular weights. Product documentation should therefore describe the blend as equal by peptide mass rather than equimolar.

Where laboratory dissolution is required, the solvent, buffer, concentration, mixing procedure, material-compatibility controls and storage conditions stated in the applicable Certificate of Analysis, Safety Data Sheet or validated laboratory method should be followed. A universal solvent instruction should not be applied to every peptide blend, counter-ion form or formulated preparation.

Research Scientific Ltd does not provide advice or recommendations concerning dosage, administration or use in humans or animals.

Declared Blend Composition

The following composition applies where the product variant is formulated at the standard 1:1 ratio by declared peptide mass. Each Laboratory Pack vial follows the composition of its stated individual vial strength.

Composition note: The values above describe nominal peptide content rather than total powder fill mass. Any carrier, bulking agent, counter-ion, residual water or other declared formulation component should be identified separately in the applicable batch documentation.

Blend-Level Chemical and Composition Information

• Product Name: BPC-157 & TB500 Blend
• Catalogue Product Identifier: PEP066
• Preferred Technical Description: Defined BPC-157 and full-length thymosin beta-4 dual-peptide mixture
• Product Type: Physical mixture of two separate sequence-defined peptide substances
• Declared Standard Ratio: 1:1 by peptide mass unless the selected product variant expressly states otherwise
• Molar-Ratio Clarification: Equal component masses do not produce equal molar quantities because BPC-157 and full-length thymosin beta-4 have different molecular weights
• Single Blend CAS Registry Number: Not applicable; the component CAS numbers should be recorded separately
• Single Blend Molecular Formula: Not applicable; the component molecular formulae should be recorded separately
• Single Blend Molecular Weight: Not applicable; the component molecular weights should be recorded separately
• Total Declared Peptide Content: Sum of the declared BPC-157 and full-length thymosin beta-4 quantities
• Total Powder Fill Mass: May exceed the declared peptide content where a carrier, bulking agent, counter-ion, residual water or other formulation component is present
• Physical Form: Dry or lyophilised laboratory preparation, as stated in the applicable batch Certificate of Analysis
• Appearance: White to off-white laboratory material where confirmed by the applicable batch documentation
• Component Purity: Chromatographic purity should be stated separately for BPC-157 and full-length thymosin beta-4
• Blend Composition: The individual peptide quantity and final ratio should be confirmed using an appropriate quantitative method
• Analytical Interpretation: Component identity, chromatographic purity, individual peptide content, blend ratio, counter-ion content, water content, residual solvents and bacterial endotoxin results are separate analytical measurements and should be interpreted together

Component 1: BPC-157 Chemical and Structural Information

• Component Name: BPC-157
• Alternative Names: Body Protection Compound-157; pentadecapeptide BPC-157; PL 14736; Bepecin
• Material Classification: Synthetic linear pentadecapeptide
• Sequence Length: 15 amino-acid residues
• Complete Peptide Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
• One-Letter Sequence: GEPPPGKPADDAGLV
• N-Terminal Structure: Free glycine amino terminus
• C-Terminal Structure: Free valine carboxylic acid terminus
• Cyclic or Linear Structure: Linear peptide
• CAS Number: 137525-51-0
• PubChem Compound Identifier: CID 9941957
• Molecular Formula: C₆₂H₉₈N₁₆O₂₂
• Average Molecular Weight: Approximately 1419.54 g/mol
• Formula Basis: The formula and molecular weight describe the uncountered BPC-157 free-acid structure without acetate, trifluoroacetate, residual water, solvents or formulation excipients
• Identity Confirmation: The complete sequence and observed molecular mass should agree with the applicable supplier and batch documentation

Component 2: Full-Length Thymosin Beta-4 Chemical and Structural Information

• Component Name: Full-Length Thymosin Beta-4
• Preferred Substance Name: Timbetasin
• Catalogue Designation: TB500
• Material Classification: Synthetic N-terminally acetylated linear peptide
• Sequence Length: 43 amino-acid residues
• Complete Modified Peptide Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
• Modified One-Letter Sequence: Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH
• N-Terminal Structure: Covalently N-acetylated serine
• C-Terminal Structure: Free serine carboxylic acid terminus
• Cyclic or Linear Structure: Linear peptide
• Cysteine Content: None
• Disulphide-Bond Content: None
• Methionine Content: One methionine residue
• CAS Number: 77591-33-4
• Unique Ingredient Identifier: 2D5MRE3SSY
• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Average Molecular Weight: Approximately 4963.5 g/mol
• Formula Basis: The formula and molecular weight describe full-length, N-terminally acetylated timbetasin without additional acetate, trifluoroacetate, residual water, solvents or formulation excipients
• Identity Confirmation: The complete 43-residue sequence, N-terminal acetylation and observed molecular mass should agree with the applicable supplier and batch documentation

Blend Formulation and Quality Documentation

✓ Separate component identity – BPC-157 and full-length thymosin beta-4 should each be supported by molecular-mass or equivalent identity data.
✓ Component-specific chromatographic purity – The high-performance liquid chromatography result for each peptide should be reported independently.
✓ Defined mass composition – The Certificate of Analysis should state the nominal and, where determined, measured quantity of each component.
✓ Blend-ratio confirmation – The final preparation should be assessed using a quantitative method suitable for confirming the declared 1:1 peptide-mass ratio.
✓ Peptide-content documentation – Net peptide content should be distinguished from chromatographic area percentage and total powder fill mass.
✓ Excipient documentation – Any carrier, bulking agent or other formulation ingredient should be identified with its applicable quantity or concentration.
✓ Chemical-form documentation – Acetate, trifluoroacetate, sodium or another counter-ion should be identified for each component where present.
✓ Water and residual-solvent documentation – Residual water and applicable process solvents should be stated or controlled through the batch specification.
✓ Oxidation-control documentation – Methionine oxidation in full-length thymosin beta-4 should be assessed or controlled where required by the applicable specification.
✓ Bacterial endotoxin documentation – The test method, reporting units, method-suitability controls, acceptance criterion and batch result should be recorded.
✓ Safety Data Sheet – Supplied to support appropriate laboratory handling, storage and regulatory compliance.
✓ Trackable laboratory delivery – Securely packaged and dispatched using transport controls appropriate to the applicable batch stability and storage specification.

For Research Use Only
This product is supplied strictly for scientific research, laboratory analysis and experimental work. It is not intended for human consumption, animal use, clinical use, diagnostic use, pharmacy compounding, self-administration or any form of therapeutic application.

BPC-157 & TB500 Blend Product Overview

Our BPC-157 and full-length Thymosin Beta-4 research-grade dual-peptide blend is supplied for controlled analytical method development, peptide identity assessment, high-performance liquid chromatography evaluation, liquid chromatography–mass spectrometry workflows, blend-composition analysis, impurity profiling, stability investigation, reference-material comparison and other scientific laboratory applications.

The formulation contains two chemically distinct peptide components combined at a defined 1:1 ratio by declared peptide mass. BPC-157 is a linear 15-residue peptide with a molecular weight of approximately 1419.54 g/mol. The TB500 component is full-length, N-terminally acetylated thymosin beta-4 or timbetasin, comprising 43 amino-acid residues and having a molecular weight of approximately 4963.5 g/mol.

Because PEP066 is a physical mixture, it has no single molecular formula, component molecular weight or CAS Registry Number. The chemical identifiers, complete sequence and analytical result for each component should be recorded independently, while the final preparation should additionally be assessed for declared component quantities and blend ratio.

Chromatographic purity should not automatically be interpreted as equivalent to total net peptide content or quantitative blend composition. Different peptide components may produce different detector responses, so a chromatographic peak-area ratio should only be treated as a mass ratio where the analytical method and response factors are suitable for that purpose.

A bacterial endotoxin or lipopolysaccharide result does not establish sterility, complete molecular identity, correct blend composition or the absence of every peptide-related and process-related impurity. Any sterility claim must be supported separately by an appropriate validated sterility test and controlled production documentation.

For the majority of routine analytical method development, chromatographic assessment, mass-spectrometry comparison, blend-characterisation, impurity profiling and general laboratory work, the Regular BPC-157 & TB500 Blend remains highly suitable. The premium black-and-gold ULTIMATE option provides additional preparative high-performance liquid chromatography purification for each peptide component and a more stringent bacterial endotoxin or lipopolysaccharide testing specification for projects requiring enhanced quality-control parameters.

View Certificate of Analysis

View Safety Data Sheet