BPC-157 ARG + KPV BLEND - Research Grade Peptide

BPC-157 ARG + KPV Blend – Research-Grade Dual-Peptide Preparation

For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, consumption, clinical use or therapeutic application. It must not be used in any way that contravenes applicable laws or the requirements of the Medicines and Healthcare products Regulatory Agency.

• Defined two-component preparation containing BPC-157 L-arginine salt and KPV tripeptide
• Standard formulation divided equally between the two declared components unless a product variant expressly states otherwise
• BPC-157 ARG defined on this page as the documented 1:2 BPC-157 di-L-arginine salt
• KPV defined on this page as the free-acid tripeptide H-Lys-Pro-Val-OH
• Supplied as measured dry or lyophilised laboratory material in sealed flip-top headspace vials
• Component identity, chromatographic purity, molecular mass, component quantity and blend composition documented in the applicable completed Certificate of Analysis where supplied
• Handled and supplied exclusively as a research-use laboratory preparation

PEP067 is a defined physical mixture containing two chemically distinct peptide-related substances: BPC-157 di-L-arginine salt and the KPV tripeptide. The two components remain separate molecular substances within the preparation and do not form a new single peptide merely because they are combined in the same vial.

Unless the selected product variant states otherwise, the total declared blend quantity is divided equally between the BPC-157 ARG component and the KPV component. For example, a 20 mg blend contains a nominal declared component allocation of 10 mg BPC-157 ARG and 10 mg KPV.

The applicable Certificate of Analysis must state whether the declared BPC-157 ARG quantity is expressed as total di-L-arginine salt mass or as BPC-157 parent-peptide equivalent. These are not interchangeable measurement bases because the accompanying L-arginine contributes to the physical mass of the salt.

Where laboratory dissolution is required, the solvent, buffer, concentration, mixing procedure, material-compatibility controls and storage conditions stated in the applicable Certificate of Analysis, Safety Data Sheet or validated laboratory method should be followed. A universal bacteriostatic-water instruction should not be applied to every peptide, salt form, blend or laboratory preparation.

Research Scientific Ltd does not provide advice or recommendations concerning dosage, administration or use in humans or animals.

Declared Blend Composition

The following table applies where the variant name represents total declared blend content and the two components are included in equal declared amounts. Each Laboratory Pack vial follows the composition shown for its individual vial strength.

Blend-Level Chemical and Composition Information

• Product Name: BPC-157 ARG + KPV Blend
• Catalogue Product Identifier: PEP067
• Preferred Technical Description: Defined BPC-157 di-L-arginine salt and KPV free-acid dual-component preparation
• Product Type: Physical mixture of two separate peptide-related substances
• Declared Standard Allocation: Equal declared component quantities unless the selected product variant states otherwise
• Mass-Basis Requirement: The Certificate of Analysis must state whether BPC-157 ARG is quantified as total di-L-arginine salt mass or as BPC-157 parent-peptide equivalent
• Molar-Ratio Clarification: Equal declared component masses do not produce equal molar quantities because the two components have different molecular weights
• Single Blend CAS Registry Number: Not applicable; component identifiers should be recorded separately
• Single Blend Molecular Formula: Not applicable; component formulae should be recorded separately
• Single Blend Molecular Weight: Not applicable; component molecular weights should be recorded separately
• Total Declared Blend Content: Sum of the declared BPC-157 ARG and KPV component quantities
• Total Powder Fill Mass: May exceed the declared component content where a carrier, bulking agent, counter-ion, residual water or other formulation component is present
• Physical Form: Dry or lyophilised laboratory preparation, as stated in the applicable batch Certificate of Analysis
• Appearance: Refer to the applicable completed batch Certificate of Analysis
• Component Purity: Chromatographic purity should be stated independently for BPC-157 ARG and KPV
• Blend Composition: Individual component quantities and the final ratio should be confirmed using an appropriate quantitative method
• Analytical Interpretation: Component identity, chromatographic purity, individual component content, salt stoichiometry, terminal structure, blend ratio, counter-ion content, water content, residual solvents and bacterial endotoxin results are separate analytical measurements and should be interpreted together

Component 1: BPC-157 ARG Chemical and Structural Information

• Component Name: BPC-157 ARG
• Preferred Technical Description: BPC-157 di-L-arginine salt
• Alternative Description: Bepecin di-L-arginine salt; Arg-BPC; BPC-157·2L-Arg
• Material Classification: Synthetic BPC-157 pentadecapeptide salt with L-arginine
• Underlying Peptide Sequence Length: 15 amino-acid residues
• Underlying BPC-157 Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
• Underlying One-Letter Sequence: GEPPPGKPADDAGLV
• Salt Stoichiometry Used on This Page: One BPC-157 peptide molecule associated with two L-arginine molecules
• Salt Notation: BPC-157·2L-Arg
• Covalent-Sequence Clarification: The L-arginine molecules are salt-forming components and are not additional covalently bonded residues in the BPC-157 peptide sequence
• Parent BPC-157 CAS Number: 137525-51-0
• Separate Salt CAS Number: No separate verified CAS Registry Number should be stated unless it is supported by the supplier and batch documentation for the exact salt form
• Parent BPC-157 Molecular Formula: C₆₂H₉₈N₁₆O₂₂
• Parent BPC-157 Average Molecular Weight: Approximately 1419.56 g/mol
• L-Arginine Molecular Formula: C₆H₁₄N₄O₂
• L-Arginine Average Molecular Weight: Approximately 174.20 g/mol
• Calculated Gross Empirical Formula for the Anhydrous 1:2 Salt: C₇₄H₁₂₆N₂₄O₂₆
• Calculated Average Formula Mass for the Anhydrous 1:2 Salt: Approximately 1767.96 g/mol
• Formula Qualification: The gross salt formula is calculated from one parent BPC-157 molecule and two L-arginine molecules and should only be used where the 1:2 stoichiometry is confirmed for the batch
• Alternative Stoichiometries: BPC-157 salts containing one or three basic amino-acid equivalents are chemically possible and would have different gross formulae and formula masses
• Nominal Amount Basis: The batch documentation must state whether the declared amount represents total salt mass or BPC-157 peptide-equivalent content
• Sequence Confirmation: The complete 15-residue BPC-157 sequence should be supported by the applicable supplier, synthesis and batch records
• Arginine-Stoichiometry Confirmation: Amino-acid analysis, quantitative assay or another suitable method should support the declared peptide-to-L-arginine relationship
• Mass-Spectrometry Confirmation: Molecular-identity data should be consistent with the BPC-157 peptide component and should be interpreted together with the separate L-arginine and salt-composition data
• Chemical-Form Confirmation: The Certificate of Analysis should distinguish BPC-157 di-L-arginine salt from BPC-157 free acid, acetate, trifluoroacetate, sodium salt and any covalently extended peptide analogue

Component 2: KPV Chemical and Structural Information

• Component Name: KPV
• Preferred Chemical Name: L-Lysyl-L-prolyl-L-valine
• Alternative Names: Lys-Pro-Val; KPV tripeptide; H-Lys-Pro-Val-OH; MSH (11–13)
• Material Classification: Synthetic linear tripeptide
• Sequence Length: Three amino-acid residues
• Complete Peptide Sequence: H-L-Lys-L-Pro-L-Val-OH
• Three-Letter Sequence: Lys-Pro-Val
• One-Letter Sequence: KPV
• N-Terminal Structure: Free L-lysine alpha-amino terminus
• Lysine Side-Chain Structure: Free epsilon-amino group
• C-Terminal Structure: Free L-valine carboxylic acid terminus
• Cyclic or Linear Structure: Linear tripeptide
• CAS Number: 67727-97-3
• PubChem Compound Identifier: CID 125672
• Molecular Formula: C₁₆H₃₀N₄O₄
• Average Molecular Weight: Approximately 342.44 g/mol
• Formula Basis: The formula and molecular weight describe the uncountered KPV free-acid structure without acetate, trifluoroacetate, residual water, solvents or formulation excipients
• KPV Amide Distinction: H-Lys-Pro-Val-NH₂ is a separate C-terminally amidated compound and should not be represented using the free-acid formula, molecular weight or CAS number stated above
• N-Acetylated KPV Distinction: Acetyl-KPV and Ac-KPV-NH₂ contain additional covalent modifications and are separate molecular substances
• Sequence Confirmation: The complete Lys-Pro-Val sequence should be supported by the applicable supplier, synthesis and batch records
• Terminal-Structure Confirmation: Molecular-identity documentation should confirm the free C-terminal valine carboxylic acid and distinguish it from a C-terminal amide
• Mass-Spectrometry Confirmation: The observed molecular mass should be consistent with the specified H-Lys-Pro-Val-OH structure
• Chemical-Form Confirmation: The applicable Certificate of Analysis should identify whether the supplied KPV is the uncountered free acid, an acetate-containing form, a trifluoroacetate-containing form or another salt presentation

Blend Formulation and Quality Documentation

✓ Separate component identity – BPC-157 ARG and KPV should each be supported by suitable molecular-identity documentation.
✓ BPC-157 ARG salt specification – The peptide-to-L-arginine stoichiometry and the basis of the declared component mass should be stated.
✓ KPV terminal-form specification – The documentation should confirm whether the supplied KPV is H-Lys-Pro-Val-OH or a different terminally modified derivative.
✓ Component-specific chromatographic purity – The high-performance liquid chromatography result for each component should be reported independently.
✓ Defined component quantities – The Certificate of Analysis should state the nominal and, where determined, measured amount of each component.
✓ Blend-ratio confirmation – The final preparation should be assessed using a quantitative method suitable for the two components and their respective detector-response characteristics.
✓ Peptide-content documentation – Net peptide or salt content should be distinguished from chromatographic area percentage and total powder fill mass.
✓ Excipient documentation – Any mannitol, carrier, bulking agent or other formulation ingredient should be identified with its applicable quantity or concentration.
✓ Chemical-form documentation – Acetate, trifluoroacetate, sodium or another counter-ion should be identified for each component where present.
✓ Water and residual-solvent documentation – Residual water and applicable process solvents should be stated or controlled through the batch specification.
✓ Bacterial endotoxin documentation – The test method, reporting units, method-suitability controls, acceptance criterion and batch result should be recorded.
✓ Safety Data Sheet – Supplied to support appropriate laboratory handling, storage and regulatory compliance.
✓ Trackable laboratory delivery – Securely packaged and dispatched using transport controls appropriate to the applicable batch stability and storage specification.

For Research Use Only
This product is supplied strictly for scientific research, laboratory analysis and experimental work. It is not intended for human consumption, animal use, clinical use, diagnostic use, pharmacy compounding, self-administration or any form of therapeutic application.

BPC-157 ARG + KPV Blend Product Overview

Our BPC-157 ARG and KPV research-grade dual-component preparation is supplied for controlled analytical method development, peptide and salt-form identity assessment, high-performance liquid chromatography evaluation, liquid chromatography–mass spectrometry workflows, blend-composition analysis, impurity profiling, stability investigation, reference-material comparison and other scientific laboratory applications.

The formulation contains BPC-157 di-L-arginine salt and the KPV free-acid tripeptide as two chemically distinct components. The BPC-157 ARG component comprises the 15-residue BPC-157 peptide associated with two L-arginine molecules, while KPV comprises the defined sequence H-Lys-Pro-Val-OH.

The calculated gross empirical formula C₇₄H₁₂₆N₂₄O₂₆ and formula mass of approximately 1767.96 g/mol apply only to an anhydrous BPC-157 di-L-arginine salt containing two L-arginine molecules per BPC-157 molecule. The batch Certificate of Analysis should confirm this stoichiometry before those values are assigned to the supplied material.

The KPV component is identified by CAS number 67727-97-3, molecular formula C₁₆H₃₀N₄O₄ and average molecular weight approximately 342.44 g/mol. These identifiers apply to H-Lys-Pro-Val-OH and not to a C-terminally amidated or N-terminally acetylated KPV derivative.

Because PEP067 is a physical mixture, the blend has no single meaningful molecular formula, component molecular weight or CAS Registry Number. The chemical identifiers and analytical results for each component should be recorded independently, while the final preparation should additionally be assessed for component quantity and declared blend ratio.

Chromatographic purity should not automatically be interpreted as equivalent to net component content or quantitative blend composition. Different molecular substances may produce different detector responses, so chromatographic peak-area percentages should only be used to calculate a mass ratio where the analytical method, reference standards and response factors are suitable for that purpose.

A bacterial endotoxin or lipopolysaccharide result does not establish sterility, complete molecular identity, correct salt stoichiometry, KPV terminal structure, blend composition or the absence of every peptide-related and process-related impurity.

For the majority of routine analytical method development, chromatographic assessment, mass-spectrometry comparison, blend characterisation, impurity profiling and general laboratory work, the Regular BPC-157 ARG + KPV Blend remains highly suitable. The premium black-and-gold ULTIMATE option provides additional preparative high-performance liquid chromatography purification for each component, enhanced blend-composition control and a more stringent bacterial endotoxin or lipopolysaccharide testing specification for projects requiring enhanced quality-control parameters.

View Certificate of Analysis

View Safety Data Sheet